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  • By Shervin Naderi, MD

    Although Collagen based fillers such as Zyplast and Cosmoderm had initially dominated the market, they fell out of favor due to their short lasting results and the potential for allergic reactions.


    Over the last five to ten years, we have seen the Hyaluronic Acid dermal fillers become the predominant work horse for most Plastic Surgeons and Dermatologists. These are used for reduction of nasolabial folds (smile lines), Marionette lines as well as other wrinkles on the face. They are used for cheek enhancement as well as lip plumbing. Tear troughs under the eyes can often be reduced using these fillers. As with any filler, a properly trained and licensed injector with good judgment and technique is the key in success and avoiding complications.

    Restylane gained FDA approval first in the United States followed by Juvederm. These two Hyaluronic Acid (HA) fillers have been the most versatile synthetic dermal fillers in the United States. Other HA fillers such as Hylaform, Captique and Prevelle never became as popular. Allergan plans on introducing a Juvederm with Lidocaine (numbing medicine) pre-mixed, in the near future.

    However Hydrelle by Coapt is already here! This is an FDA approved HA filler with a higher concentration of HA molecule and Lidocaine added. The higher concentration of HA molecules mean that 1cc of Hydrelle will give you more HA and volume and wrinkle correction than 1cc of Restylane or Juvederm. The added numbing medicine means that patients who require several shots in the same area for fine contouring will have less pain and more comfort during the procedure.

    There is no one great filler. Each patient needs a unique assessment and approach. For those who are happy with Restylane or Juvederm then I would recommend sticking to what you like and what works best for you. But for those who want to try something new, then Hydrelle may be worth a shot!

    You can find out more here:


    Ask Shervin Naderi a question on Makemeheal.com.



    4 Comments so far

    1. Dave on September 25, 2009 8:08 am

      I had Hydrelle and it worked wonderfully…comfortable and required less filler. It only took 1-syringe to soften my naso-labial folds and oral commisures. It was comfortable and the Injector did not have to use a dental block or other anesthetic. I love it!

    2. Dr. Naderi on December 22, 2009 7:15 pm

      There have been a series of doctors who have come forth with major complaints about Hydrelle which the company has not taken seriously, forcing us to take action with the FDA to try to remove this product. The company blames doctors for their injection technique or volume where the real problem is the actual Hydrelle substance.

    3. Shelley on March 4, 2010 3:14 pm

      Stay away from this product. Avoid. Do not try. Forget about it. I don’t know what more I can say to convince you to never, ever consider this product. I have been suffering for over 4 months and just now I am seeing nodules on the other side of my face for the 1st time. Hydrelle should be pulled from the market. The FDA is a joke.

    4. Jennifer on April 4, 2010 2:43 pm

      Save yourself from the nightmare. I am in a world of pain and have huge swollen (atleast 3x normal size) and lumpy lips – for over 4 weeks now. Dr is trying everything to treat it but the reaction just won’t stop. This morning I woke up and my nasal cavities were even swelling up and I could barely breath out of my nose. All from lip injections! I just hope that my lips will return to normal soon and won’t be scarred for life. Do not even think about using this product. The company is not even returning my plastic surgeons phone calls! It’s a joke!

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